(Sr.)Scientist (CMC-PD)

We are currently seeking a

(Sr.) Scientist

to support our team. This position will work in Houston, Texas and will be responsible for the process and product development for GMP manufacturing of engineered, autologous, or allogeneic T cells used in Adoptive Cell Therapies for cancer patients.

Job Overview

This includes, but is not limited to using  in-depth knowledge of, T-cell biology, Immunology preferably in the context of adoptive cellular therapy, to improve the manufacturability of patient specific T-cell products for clinical use in various phases of clinical trials and commercial manufacturing. As part of a collaborative, highly spirited, hardworking team, the incumbent will enjoy a rare opportunity to see the results of his/ her efforts directly translated to the clinic.  

Overall Responsibilities

The main responsibilities of this position will include but are not limited to the following tasks: 

  • Process development and optimization for Immatics’ proprietary genetically modified autologous and allogeneic T cell immunotherapy programs  
  • Contribute conceptually and experimentally towards optimizations of various steps for development of a robust process for manufacturing with patient material 
  • Understand challenges of T cell manufacturing and devise strategies to overcome those challenges 
  • Lead establishment of next generation manufacturing platforms and technologies for continued development towards advanced stage clinical trials 
  • Phenotypic and functional characterization of T cell products 
  • Provide scientific insights and recommendations to the Department’s strategy  
  • Provide technical writing support for IND submissions and the required study reports needed  
  • Support of day-to-day operations within CMC (Process Development and GMP manufacturing)  
  • Provide technical support and expertise to GMP manufacturing group of CMCs throughout clinical trials by provided technical knowledge about T-cell products  
  • Other duties as assigned  

Qualification

  • REQUIRED: Ph.D in Immunology, Biochemistry, Molecular Biology or closely related field. 
  • PREFERRED: Strong background in T Cell biology and immunology and understanding of the field of engineered CAR-T and/or TCR-T Cells.  
  • Three (3) years of experience with CAR-T and/or TCR-T cell generation, scale up for GMP manufacturing and product characterization 
  • Overall familiarity and understanding of various manufacturing platforms such as Prodigy, Xuri, G-Rex  
  • Experience with processing devices such as CliniMACS, SEPAX, LOVO etc. is a plus  
  • Experience in designing of viral vector constructs and proficiency in using Snapgene or similar softwares   
  • Experience in flow cytometry, cytotoxicity assays, cytokine release assays and other analytical techniques (e.g. qPCR). 
  • Understanding of transfection/transduction of cell lines and primary human cells. 
  • Working in a regulated environment (writing research reports, SOPs, and IND sections). 
  • PREFERRED: Experience in the biotech/pharma industry and experience managing both people and projects. 

We expect a high degree of independent working, analytical reasoning and excellent communication skills. You embrace rapidly changing requirements with an open mind, think outside the box and show a high degree of flexibility in an environment which is marked by a constant striving for excellence. You approach tasks in a structured,
reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills.

What We Offer

We are a committed and inspired team and cherish the collegial, highly motivated and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking and initiative. We believe in supporting our employees’ professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits – e.g. job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.

We are a committed and inspired team and cherish the collegial, highly motivated and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking and initiative. We believe in supporting our employees’ professional and social skills. Immatics offers partial subsidized health, dental and vision insurance, 401(k), 160 hours of PTO annually, paid holidays, paid parking, paid short/long term disability/AD&D and life insurance.

If you’re interested in working for Immatics, please forward your CV along with a letter of introduction via e-mail to RecruitingUS@immatics.com. For more detailed information about Immatics and privacy protection visit www.immatics.com.

Job Posting: (Sr.)Scientist – GMP (all genders welcome)

Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Immatics US’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Immatics US, and no fee/payment will be paid. Recruiters interested in working with Immatics US can submit their information to HR-US@imamtics.com, and we will contact you if needed.